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Kamagra is a drug used in erectile dysfunction. It restores reduced erectile function, increasing blood flow to the penis. The mechanism of action is based on the release of nitric oxide in the cavernous bodies at the time of sexual excitement. Free nitric oxide activates the guanylate cyclase enzyme, stimulating an increase in cGMP, which causes relaxation of the smooth muscle fibers of the corpora cavernosa and an increase in blood flow.
Indications
Generic Kamagra is used in men suffering from erectile dysfunction (inability to achieve or maintain an erection which ensures successful sexual intercourse).
Dosage and administration
Kamagra is used orally. For the effective action of this drug, sexual excitement is necessary. The pill is taken an hour before sexual intercourse. The recommended single dose is 50 mg (preferably on an empty stomach). The maximum single dose is 100 mg.
Overdose
Possible symptoms: visual impairment, headache, flushing, dyspepsia, dizziness, nasal congestion. In case of an overdose, standard supportive measures are conducted.
Contraindications
- Hypersensitivity to any component of the drugs;
- Simultaneous administration of drugs relating to nitric oxide (amyl nitrite) or nitrates in any form;
- Severe liver failure;
- Hereditary degenerative diseases of the retina (for example, hereditary retinitis pigmentosa (a small number of these patients have hereditary dysfunctions of the retinal phosphodiesterases);
- Loss of vision in one eye due to anterior non-arteritic ischemic neuropathy of the optic nerve, regardless of whether this episode was associated with previous use of a PDE-5 inhibitor;
- Hypotension;
- Severe cardiovascular disease (e.g., severe heart failure, unstable angina)myocardial infarction suffered in the last 6 months;
- Stroke during the previous 6 months;
- Men with rare hereditary galactose intolerance, Lapp lactase deficiency or glucose and galactose malabsorption syndrome;
- Concomitant use with other oral or local agents for the treatment of erectile dysfunction.
Side effects
- Very often: headache
- Often: dizziness, color distortions of vision, visual disturbance, blurred vision, flushing, hot flashes, nasal congestion, dyspepsia, nausea.
- Infrequently: rhinitis, hypersensitivity, drowsiness, hypesthesia, disorders associated with lacrimation, eye pain, photophobia, photopsia, hyperemia of eyes’ vessels, brightness of visual perception, conjunctivitis, spatial disorientation (vertigo), tinnitus, tachycardia, palpitations, arterial hypertension, arterial hypotension, nosebleeds, sinus congestion, pain in the upper abdomen, gastroesophageal reflux disease, vomiting, dry mouth, rash, myalgia, pain in the limbs, hematuria, chest pain, fatigue, fever, increased heart rate.
- Seldom: acute cerebrovascular accident, transient ischemic attack, convulsive attack, relapse of a convulsive attack, fainting, anterior non-arteritic ischemic optic nerve neuropathy, retinal vascular occlusion, retinal hemorrhage, arteriosclerotic retinopathy, retinal disease, glaucoma, visual field defect, diplopia, decreased visual acuity, myopia, asthenopia, floating vitreous opacities, swelling of the eyes, visual disturbances, conjunctival hyperemia, eye irritation, unusual sensation in the eye, swelling of the eyelids, discoloration of the sclera, deafness, sudden cardiac death, myocardial infarction, ventricular arrhythmia, atrial fibrillation, unstable angina, a feeling of tightness in the throat, swelling of the nose, dryness of the nasal mucosa, oral hypesthesia, Stevens-Johnson syndrome, toxic epidermal necrolysis, bleeding from the penis, priapism.
Interaction with other medications and alcohol
You should not use the drug if you are already using some kind of medication to increase potency, otherwise, an overdose is possible. Also, do not combine sildenafil with a number of cardiac drugs. In general, when taking various other substances, only the physician can indicate the exact consequences of their interaction, since in many respects everything depends on the dose. Do not combine the drug with alcohol. Alcohol at high concentration negatively affects an erection. When taking Kamagra simultaneously with alcohol, it can reduce the drug effect.